Vaccines have promised, to the rest of the world, a return to a semblance of normal life … But they were not designed for, or tested extensively on, immunocompromised or immunosuppressed individuals, whose immune systems have been subdued by underlying conditions, environmental exposures, drugs, or viruses such as HIV. With their defenses down, many of these people can’t yet count on what the rest of us can: that the new shots will protect them from the coronavirus.