From California to Pennsylvania, governors and mayors across the U.S. are ratcheting up COVID-19 restrictions amid the record-shattering resurgence of the virus that is all but certain to get worse because of holiday travel and family gatherings over Thanksgiving. Leaders are closing businesses or curtailing hours and other operations, and they are ordering or imploring people to stay home and keep their distance from others to help stem a rising tide of infections that threatens to overwhelm the health care system. “I must again pull back the reins,” New Jersey Gov. Phil Murphy said Monday as he restricted indoor gatherings to 10 people, down from 25. “It gives me no joy.” California Gov. Gavin Newsom announced he is pulling the “emergency brake” on efforts to reopen the economy, saying the state is experiencing the fastest growth in cases yet, and if left unchecked, it will lead to “catastrophic outcomes.”